Common name |
B-hPSMA MC38 | Catalog number | 310840 |
Aliases | / | Disease | Colon carcinoma |
Organism |
Mouse |
Strain | C57BL/6 |
Tissue types | Colon | Tissue | Colon |
Description
B-hPSMA MC38 cells have the capability to establish tumors in vivo and can be used for efficacy studies.
Targeting strategy
Subcutaneous homograft tumor growth of B-hPSMA MC38 cells. B-hPSMA MC38 cells (5x105) and MC38 cells (5x105) were subcutaneously implanted into C57BL/6 mice (female, 7-week-old, n=5). Tumor volume and body weight were measured twice a week. Volume was expressed in mm3 using the formula: V=0.5 × long diameter × short diameter2. (A) Average tumor volume ± SEM. (B) Body weight (Mean± SEM). (C) Tumor cells were harvested and assessed for human PSMA expression by flow cytometry. As shown in panel, B-hPSMA MC38 cells were able to establish tumors in vivo but human PSMA was not expressed on the surface of tumor cells.