| Strain Name |
NOD.CB17-Prkdcscid Il2rgtm1Bcgen Igs2tm1(HLA-A2.1-B2M/HLA-A11.1)Bcgen H2-K1tm1Bcgen H2-D1tm1Bcgen/Bcgen |
Common Name |
B-NDG hB2M/HLA-A11.1 mice plus |
| Background | B-NDG | Catalog number | 112474 |
| Aliases |
IMD43; HLAA |
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Protein expression analysis
Frequency of leukocyte subpopulations
Frequency of leukocyte subpopulations in bone marrow, spleen and blood by flow cytometry. Bone marrow, splenocytes and blood cells were isolated from B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus (male,7-week-old, n=3). A. Flow cytometry analysis of the immune cells was performed to assess the frequency of leukocyte subpopulations. Frequencies of T cells, B cells, NK cells, DCs, neutrophils, monocytes and macrophages in B-NDG hB2M/HLA-A11.1 mice plus were similar to those in B-NDG mice, demonstrating that humanization of HLA-A11.1 does not change the frequency or distribution of these cell types in bone marrow, spleen and blood when compared with those in B-NDG mice. Values are expressed as mean ± SEM.
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