B-MUP-uPA mice
| Strain Name |
C57BL/6-Hipp1tm2(MUP-uPA)Bcgen/Bcgen
|
Common Name | B-MUP-uPA mice |
| Background | C57BL/6 | Catalog number | 112036 |
| Aliases |
uPA; u-PA |
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模型验证
Mouse uPA mRNA expression analysis by RT-qPCR
ALT and AST concentrations in serum
uPA expression analysis in B-MUP-uPA mice by RT-qPCR. Liver and kidney tissues were collected from wild-type C57BL/6 mice (+/+) and heterozygous B-MUP-uPA mice (Mut/+) (n=3, female, 9-week-old). Mouse uPA was specific expression in the liver of heterozygous B-MUP-uPA mice and the level was higher than that in the wild-type.
Serum ALT and AST analysis in B-MUP-uPA mice. Serum was collected from wild-type C57BL/6 mice (+/+) and heterozygous B-MUP-uPA mice (Mut/+) (n=10, male). Serum ALT and AST concentrations were normal in B-MUP-uPA mice at 3 weeks of age, but elevated and up to peek in 5 weeks. Indicating that occurs liver injury in B-MUP-uPA mice. (Data shows in Mean±SEM)
Serum ALT and AST analysis in B-MUP-uPA mice. Serum was collected from wild-type C57BL/6 mice (+/+), heterozygous B-MUP-uPA mice (Mut/+) and homozygous B-MUP-uPA mice (Mut/Mut) (n=6, male). Serum uPA concentrations were normal in B-MUP-uPA mice at 4 weeks of age, but elevated and up to peek in 6 weeks. Indicating that occurs liver injury in B-MUP-uPA mice. (Data shows in Mean±SEM)
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