B-hNTRK3 mice
| Strain Name |
C57BL/6-NtrK3tm1(NTRK3)Bcgen/Bcgen
|
Common Name | B-hNTRK3 mice |
| Background | C57BL/6 | Catalog number | 111071 |
| Aliases |
NTRK3, GP145-TrkC, TRKC, gp145(trkC), neurotrophic receptor tyrosine kinase 3 |
||
模型验证
mRNA expression analysis
Strain specific analysis of NTRK3 gene expression in wild type (WT) mice and B-hNTRK3 mice by RT-PCR. Mouse Ntrk3 mRNA was detectable only in cerebellum of WT mice (+/+). Human NTRK3 mRNA was detectable only in homozygous B-hNTRK3 mice (H/H) but not in WT mice (+/+).
Protein expression analysis
Strain specific NTRK3 expression analysis in homozygous B-hNTRK3 mice by western blot. Brain, cerebellum, stomach, liver and colon were collected from wild type (WT) mice (+/+) and homozygous B-hNTRK3 mice (H/H), and analyzed by western blot with anti-NTRK3 antibody. NTRK3 was not detectable in liver of WT mice (+/+) and homozygous B-hNTRK3 mice (H/H). NTRK3 was detectable in brain, cerebellum, stomach and colon of WT mice (+/+) and homozygous B-hNTRK3 mice (H/H) due to the cross-reactivity of antibodies.
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