B-hIL17RA/hIL17RC mice
| Strain Name | C57BL/6-Il17ratm1(IL17RA)BcgenIl17rctm1(IL17RC)Bcgen/Bcgen | Common Name | B-hIL17RA/hIL17RC mice |
| Background | C57BL/6 | Catalog number | 120555 |
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Aliases |
IL17RA: CD217, IL17R, IMD51, CANDF5, CDw217, IL-17RA, hIL-17R IL17RC: CANDF9, IL17RL, IL17-RL |
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模型验证
Protein expression analysis of IL17RA in macrophages from spleen
Protein expression analysis of IL17RA in macrophages from bone marrow
Protein expression analysis of IL17RC in spleen
Protein expression analysis of IL17RC in bone marrow
mRNA expression analysis of IL17RC
Strain specific IL17RA expression analysis in C57BL/6 wild-type and homozygous B-hIL17RA/hIL17RC mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 (+/+) and homozygous B-hIL17RA/hIL17RC mice (H/H, H/H), and analyzed by flow cytometry with species-specific anti-IL17RA antibody. mIL17RA was only detectable in wild-type mice and hIL17RA were only detectable in macrophages of spleen from homozygous mice.
Strain specific IL17RA expression analysis in C57BL/6 wild-type and homozygous B-hIL17RA/hIL17RC mice by flow cytometry. Bone marrow cells were collected from wild-type C57BL/6 (+/+) and homozygous B-hIL17RA/hIL17RC mice (H/H, H/H), and analyzed by flow cytometry with species-specific anti-IL17RA antibody. mIL17RA was only detectable in wild-type mice and hIL17RA were only detectable in macrophages of bone marrow from homozygous mice.
Strain specific IL17RC expression analysis in C57BL/6 wild-type and homozygous B-hIL17RA/hIL17RC mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 (+/+) and homozygous B-hIL17RA/hIL17RC mice (H/H, H/H), and analyzed by flow cytometry with species-specific anti-IL17RC antibody. mIL17RC and hIL17RC were detectable in DCs, monocytes, macrophages and neutrophils from wild-type and homozygous mice, as anti-mouse IL17RC and anti-human IL17RC antibody were both cross-reactive between human and mouse.
Strain specific IL17RC expression analysis in C57BL/6 wild-type and homozygous B-hIL17RA/hIL17RC mice by flow cytometry. Bone marrow cells were collected from wild-type C57BL/6 (+/+) and homozygous B-hIL17RA/hIL17RC mice (H/H, H/H), and analyzed by flow cytometry with species-specific anti-IL17RC antibody. mIL17RC and hIL17RC were detectable in DCs, monocytes, macrophages and neutrophils from wild-type and homozygous mice, as anti-mouse IL17RC and anti-human IL17RC antibody were both cross-reactive between human and mouse.
Strain specific analysis of IL17RC mRNA expression in wild-type C57BL/6 mice and B-hIL17RA/IL17RC mice by RT-PCR. Colon RNA were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hIL17RA/hIL17RC mice (H/H), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mouse or human IL17RC primers. Mouse Il17rc mRNA was detectable only in wild-type C57BL/6 mice. Human IL17RC mRNA was detectable only in homozygous B-hIL17RA/hIL17RC mice but not in wild-type mice.
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